Iron-Catalyzed Diastereoselective Intramolecular Olefin Aminobromination with Bromide Ion

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asymmetric intramolecular olefin aminochlorination using chloride ion†

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ole fi n aminochlorination using chloride ion †

An iron-catalyzed enantioselective and diastereoselective intramolecular olefin aminochlorination reaction is reported (ee up to 92%, dr up to 15 : 1). In this reaction, a functionalized hydroxylamine and chloride ion are utilized as nitrogen and chlorine sources, respectively. This new method tolerates a range of synthetically valuable internal olefins that are all incompatible with existing a...

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ژورنال

عنوان ژورنال: Synthesis

سال: 2015

ISSN: 0039-7881,1437-210X

DOI: 10.1055/s-0034-1378719